What Is PDRN Serum? Complete Guide + Honest Review of Centellian24 Best Sellers
Korean skincare continues to lead global beauty trends, and one ingredient gaining major attention is PDRN (Polydeoxyribonucleotide).
Often associated with skin regeneration and elasticity care, PDRN serums are now widely available in cosmetic formulations — especially in premium K-beauty brands.
In this article, we will explore:
What PDRN is and how it works
Who should use a PDRN serum
How to apply it properly
Honest review of two popular serums from Dongkook Pharmaceutical
What Is PDRN?
PDRN (Polydeoxyribonucleotide) is a DNA-derived ingredient known for supporting:
✔ Skin repair
✔ Moisture retention
✔ Elasticity improvement
✔ Skin barrier strengthening
Originally used in dermatology treatments, PDRN has now been adapted into cosmetic skincare formulations.
⚠ Important Note: Cosmetic PDRN serums are different from medical injection treatments. They support skin condition over time but are not medical procedures.
Why Is PDRN Popular in Korean Skincare?
K-beauty focuses on:
Skin barrier health
Gentle regeneration
Long-term hydration
Anti-aging prevention
PDRN fits perfectly into this philosophy. It is especially suitable for:
Dry or dehydrated skin
Sensitive skin
Aging skin concerned with elasticity
Skin recovering from irritation
Review: Dongkook Pharmaceutical Centellian24 PDRN Serums
Dongkook Pharmaceutical is a well-known Korean pharmaceutical company with strong research background in Centella Asiatica (Cica) ingredients. Their skincare line Centellian24 combines medical research with cosmetic innovation.
1️⃣ Centellian24 360° Shot PDRN Active Serum
Key Features
Contains PDRN complex
Focused on elasticity and firming care
Hydrating yet slightly rich texture
Pump packaging for hygienic use
Texture & Application
The serum has a slightly viscous, cushion-like texture. It spreads smoothly and leaves a subtle glow. Some users may find it mildly tacky, but it absorbs well after layering.
Results After 2–3 Weeks (User Experience Summary)
Skin feels firmer
Improved smoothness
Healthier glow
Good base under makeup
Best For:
✔ Early anti-aging care
✔ Dry or combination skin
✔ Night routine elasticity focus
2️⃣ Centellian24 Madeca Micro Startok Serum
Key Features
Combines PDRN + peptide complex
Includes Centella Asiatica extract
Functional brightening & wrinkle-care formula (Korean cosmetic standard)
More nourishing texture
Texture & Application
This serum feels richer and more concentrated. Ideal for evening skincare routines. A small amount is enough.
User Experience Summary
Noticeably softer skin next morning
Improved skin texture
Deep hydration effect
Slightly heavier finish than 360 Shot version
Best For:
✔ Dry skin
✔ Night repair routine
✔ Skin needing intensive nourishment
How To Use PDRN Serum Correctly
Morning Routine:
Cleanser
Toner
PDRN Serum
Moisturizer
Sunscreen
Night Routine:
Double cleanse
Toner
PDRN Serum
Cream
💡 Pro Tip:
Apply 2–3 pumps and gently press into skin instead of rubbing aggressively.
Which One Should You Choose?
| Concern | Recommended Option |
|---|---|
| Firming & daily elasticity | 360° Shot PDRN Active Serum |
| Deep nourishment & night repair | Madeca Micro Startok Serum |
| Sensitive skin recovery | Either (patch test recommended) |
| First-time PDRN user | 360° Shot (lighter texture) |
Final Thoughts: Is PDRN Worth It?
PDRN serums are not overnight miracle products. However, with consistent use, many users report:
Improved skin resilience
Better hydration balance
Subtle firming
Healthier glow
If you are exploring Korean anti-aging skincare beyond traditional vitamin C or retinol, PDRN can be a gentle yet effective addition to your routine.
Centellian24 products from Dongkook Pharmaceutical are especially appealing for consumers who prefer derma-inspired Korean skincare backed by pharmaceutical research.
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